ACETONE
Denaturant; Fragrance Ingredient; Solvent
Also listed as
DIMETHYLFORMALDEHYDE; DIMETHYL KETONE; METHYL KETONE; 2-PROPANONE; 2-PROPANONE; ACETON (GERMAN, DUTCH, POLISH) ; ACETONE (ACGIH:OSHA) ; BETA-KETOPROPANE; CHEVRON ACETONE; DIMETHYL KETONE; DIMETHYLFORMALDEHYDE
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
 | Developmental/reproductive toxicity |
 | Restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
 | Other strong concerns for this ingredient: Irritation (skin, eyes, or lungs) |
| Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive), Occupational hazards |
| Lesser or emerging concerns for this ingredient: Data gaps |
|
See products containing ACETONE | |
About ACETONE: Acetone is the aliphatic ketone.
ACETONE has reported used in the following product types: polish remover (18); nail polish (13); pain relief (4); muscle/joint soreness (4); wound treatment (3); exfoliant/scrub (3); bandages (3); facial cleanser (3); acne treatment (3); facial moisturizer/treatment (3)
Neurotoxicity
| type of concern | product conditions | reference |
| Strong evidence of human neurotoxicity | Chemicals known to be neurotoxic to humans | |
| show more | ||
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| Human nervous system toxicant - moderate evidence | Chemicals known to be neurotoxic to humans | |
| show more | ||
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| Classified as medium human health priority | Environment Canada Domestic Substance List | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005 |
| Possible human cardiovascular toxicant | CHE Toxicant and Disease Database | |
| Classified as expected to be toxic or harmful | Environment Canada Domestic Substance List | |
| One or more animal studies show sense organ effects at very low doses | products for use around the eyes, mouth, or lips | RTECS®- American Journal of Ophthalmology 1946 |
| show more | ||
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- Food and Chemical Toxicology 1984 | |
| show more | ||
Irritation (skin, eyes, or lungs)
| type of concern | product conditions | reference |
| Classified as irritant | European Union - Classification & Labelling | |
| show more | ||
Occupational hazards
| type of concern | product conditions | reference |
| Allowed workplace exposures restricted to high doses | RTECS®- TLV/BEI,2007 | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 4,790 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Miscellaneous
| type of concern | product conditions | reference |
| Occupational hazards related to handling | European Union - Classification & Labelling |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food | |
| Designated as safe for general or specific, limited use in food | FDA Food Additive Status |
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| European Union - Classification & Labelling | ACETONE;;PROPAN-2-ONE; PROPANONE | •Highly flammable •Highly flammable •Irritant (eyes, skin, or lungs) |
| FDA Food Additive Status | ACETONE | • Food additive: solvent • Food additive: food additive for which a petition has been filed and a regulation issued • 30 parts per million - As residual solvent in spice oleoresins 173.210 |
| Association of Occupational and Environmental Clinics | ACETONE | • S |
| Association of Occupational and Environmental Clinics | ACETONE | • S |
| Association of Occupational and Environmental Clinics | ACETONE | • S |
| CHE Toxicant and Disease Database | ACETONE | •Limited evidence in humans: reproductive system toxicity; Condition: abnormal sperm (morphology, motility, and sperm count); Organs/tissues affected: testes |
| CHE Toxicant and Disease Database | ACETONE | •Moderate evidence in humans: cardiovascular system toxicity; Condition: arrhythmias; Organs/tissues affected: heart |
| EPA Water Disinfection By-Products Carcinogenicity | ACETONE | •Low concern for potential carcinogenicity |
| FDA Everything Added to Food | ACETONE | • Fully up-to-date toxicology information has been sought. |
| EPA Integrated Risk Information System (IRIS) | ACETONE | Data are inadequate for an assessment of human carcinogenic potential |
| National Library of Medicine HazMap | ACETONE | •Neurotoxin: CNS Solvent Syndrome; •PEL (OSHA) - Permissible exposure limit (OSHA): 1000 ppm; •STEL (ACGIH) - Short-term exposure limits (ACGIH): 750 ppm; •RD50 - Concentration producing a 50% decrease in respiratory rate in experimental animals following a 10-minute exposure: 23480 ppm; •LC50 - Lethal concentration in 50% of animals tested: 51755 ppm; •TLV (ACGIH) - Threshold limit value (ACGIH): 500 ppm; •BEI - Biological Exposure Indices (American Conference of Governmental Industrial Hygiene, ACGIH): Acetone in urine = 50 mg/L; end of shift;; •Flammability (NFPA) - NFPA flammability code: 0 = will not burn; 1 = must be preheated; 2 = high ambient temp required; 3 = may ignite at ambient temp; 4 = burn readily: 3: may ignite at ambient temperature; •IDLH (NIOSH) - Immediately Dangerous to Life or Health: 2500 ppm; •Odor Threshold High - The lowest concentration at which a substance can be detected or recognized using the sense of smell: 653 ppm; •Odor Threshold Low - The lowest concentration at which a substance can be detected or recognized using the sense of smell: 3.6 ppm; •MAK - Maximum Allowable Concentration (Federal Republic of Germany): 500 ppm; |
| Chemicals known to be neurotoxic to humans | ACETONE | •Known to be neurotoxic to humans, suspected developmental neurotoxin |
| EPA Toxic Release Inventory PBTs | ACETONE | •Toxic, U.S. Environmental Protection Agency Toxics Release Inventory programs |
| Agency for Toxic Substances and Disease Registry, 2004 | ACETONE | •Cardiovascular or blood toxicity hazards: suspected |
| Environment Canada Domestic Substance List | 2-PROPANONE | •This chemical was deemed a moderate human health priority and was flagged by CEPA for further attention. The chemical was flagged for suspected persistence. |
| IFRA Fragrance Ingredient List | 2-PROPANONE | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| RTECS®- TLV/BEI,2006 | ACETONE | • occupationally related - ACGIH TLV (human TWA) |
| RTECS®- TLV/BEI,2007 | ACETONE | • occupationally related - ACGIH TLV (human TWA) |
| RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 | ACETONE | • sense organ - Primary eye irritant (rabbit ) • skin - Primary skin irritant (rabbit ) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | ACETONE | • mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (mouse ihl) |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | ACETONE | • mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (mouse ihl) |
| RTECS®- American Journal of Ophthalmology 1946 | ACETONE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Annals of the New York Academy of Sciences 1983 | ACETONE | • mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Saccharomyces cerevisiae ) |
| RTECS®- Annals of the New York Academy of Sciences 1983 | ACETONE | • mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Saccharomyces cerevisiae ) |
| RTECS®- CRC Critical Reviews in Toxicology 2002 | ACETONE | • sense organ - Primary eye irritant ( human ) |
| RTECS®- CRC Critical Reviews in Toxicology 2002 | ACETONE | • sense organ - Primary eye irritant ( human ) |
| RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005 | ACETONE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Food and Chemical Toxicology 1984 | ACETONE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
| RTECS®- Food and Chemical Toxicology 1984 | ACETONE | • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster fbr) |
| RTECS®- Journal of Industrial Hygiene and Toxicology 1943 | ACETONE | • sense organ - Primary eye irritant ( human ) |
| RTECS®- Journal of Toxicologic Pathology 2001 | ACETONE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- Journal of Toxicologic Pathology 2001 | ACETONE | • sense organ - Primary eye irritant (rabbit ) |
| RTECS®- MSHA STANDARD-air: 3,3,1971 | ACETONE | • occupationally related - MSHA STANDARD-air (human TWA) |
| RTECS®- National Technical Information Service 5975 | ACETONE | • reproductive - Spermatogenesis (rat TDLo) |
| RTECS®- National Toxicology Program Technical Report Series 3122 | ACETONE | • kidney or renal system - Changes in bladder weight (rat TDLo) • liver - Changes in liver weight (rat TDLo) • blood - Normocytic anemia (rat TDLo) |
| RTECS®- OSHA PEL (Construc): 29,1926 1994 | ACETONE | • occupationally related - OSHA PEL (Construc) (human TWA) |
| RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994 | ACETONE | • occupationally related - OSHA PEL (Fed Cont) (human TWA) |
| RTECS®- OSHA PEL (Gen Indu): 29,1910 1994 | ACETONE | • occupationally related - OSHA PEL (Gen Indu) (human TWA) |
| RTECS®- OSHA PEL (Shipyard): 29,1915 1993 | ACETONE | • occupationally related - OSHA PEL (Shipyard) (human TWA) |
| RTECS®- Union Carbide Data Sheet 1970 | ACETONE | • skin - Primary skin irritant (rabbit ) |
references
| government/industry list/academic study | reference |
| European Union - Classification & Labelling | CPS&Q (Consumer Products Safety & Quality) formely known as ECB (European Chemicals Bureau). 2008. Classification and Labelling: Chemicals: Annex VI of Directive 67/548/EEC through the 31st ATP. |
| FDA Food Additive Status | FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006. |
| Association of Occupational and Environmental Clinics | AOEC (Association of Occupational and Environmental Clinics). 2009. AEOC exposures codes and asthmagen designation. |
| CHE Toxicant and Disease Database | CHE (The Collaborative on Health and the Environment). 2006. Toxicant and Disease Database. |
| EPA Water Disinfection By-Products Carcinogenicity | EPA (U.S. Environmental Protection Agency). 2006. EPA Water Disinfection By-Products with Carcinogenicity Estimates. Last updated: 10 April 2006. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| EPA Integrated Risk Information System (IRIS) | EPA (U.S. Environmental Protection Agency). 2008. Integrated Risk Information System (IRIS). Evidence for human carcinogenicity based on 1986-2005 guidelines. |
| National Library of Medicine HazMap | NLM (National Library of Medicine). 2006. HazMap — Occupational Exposure to Hazardous Agents. |
| Chemicals known to be neurotoxic to humans | Grandjean P and PJ Landrigan. 2006. Developmental neurotoxicity of industrial chemicals. Lancet. 2006 Dec 16;368(9553):2167-78. |
| EPA Toxic Release Inventory PBTs | EPA (U.S. Environmental Protection Agency). 1999. Toxics Release Inventory Program. PBT Chemical Rule. |
| Scorecard.org Toxicity Information | Agency for Toxic Substances and Disease Registry. Minimal risk Levels for Hazardous Substances. January 2004. http://www.atsdr.cdc.gov/mrls.html, Klaassen, C., M. Amdur and J. Doull (eds.). Casarett and Doull's Toxicology. The Basic Science of Poisons, 5th Ed. Pergamon Press, NY. 1996. |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| RTECS®- TLV/BEI,2006 | RTECS®- TLV/BEI,2006 |
| RTECS®- TLV/BEI,2007 | RTECS®- TLV/BEI,2007 |
| RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J 1986 | RTECS®- "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 -,280,1986 |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994 -,409,1994 |
| RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia" 1994 | RTECS®- "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994. -,409,1994 |
| RTECS®- American Journal of Ophthalmology 1946 | RTECS®- American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918- 29,1363,1946 |
| RTECS®- Annals of the New York Academy of Sciences 1983 | RTECS®- Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877- 407,186,1983 |
| RTECS®- Annals of the New York Academy of Sciences 1983 | RTECS®- Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 407,186,1983 |
| RTECS®- CRC Critical Reviews in Toxicology 2002 | RTECS®- CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 32,43,2002 |
| RTECS®- CRC Critical Reviews in Toxicology 2002 | RTECS®- CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971- 32,43,2002 |
| RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005 | RTECS®- Encyclopedia of Toxicology: Reference Book, Elsevier, 2005 -,27,2005 |
| RTECS®- Food and Chemical Toxicology 1984 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 22,623,1984 |
| RTECS®- Food and Chemical Toxicology 1984 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 22,623,1984 |
| RTECS®- Journal of Industrial Hygiene and Toxicology 1943 | RTECS®- Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU. 25,282,1943 |
| RTECS®- Journal of Toxicologic Pathology 2001 | RTECS®- Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988 29,187,2001 |
| RTECS®- Journal of Toxicologic Pathology 2001 | RTECS®- Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 29,187,2001 |
| RTECS®- MSHA STANDARD-air: 3,3,1971 | RTECS®- MSHA STANDARD-air: 3,3,1971 |
| RTECS®- National Technical Information Service 5975 | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB91-185975 |
| RTECS®- National Toxicology Program Technical Report Series 3122 | RTECS®- National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- NIH-91-3122 |
| RTECS®- OSHA PEL (Construc): 29,1926 1994 | RTECS®- OSHA PEL (Construc): 29,1926.55,1994 |
| RTECS®- OSHA PEL (Fed Cont): 41,50-204 1994 | RTECS®- OSHA PEL (Fed Cont): 41,50-204.50,1994 |
| RTECS®- OSHA PEL (Gen Indu): 29,1910 1994 | RTECS®- OSHA PEL (Gen Indu): 29,1910.1000,1994 |
| RTECS®- OSHA PEL (Shipyard): 29,1915 1993 | RTECS®- OSHA PEL (Shipyard): 29,1915.1000,1993 |
| RTECS®- Union Carbide Data Sheet 1970 | RTECS®- Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) 5/7/1970 |
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