AMMONIUM GLYCYRRHIZATE
Flavoring Agent; Fragrance Ingredient; Skin-Conditioning Agent - Miscellaneous; MASKING; SKIN CONDITIONING
Also listed as
AMMONIUM GLYCYRRHIZINATE; A-D-GLUCOPYRANOSIDURONIC ACID,; (3B,20B ) -20-CARBOXY-11-OXO-30-NORLEAN-12-EN-3-YL-2-O-B -D-GLUCOPYRANURONOSYL-, AMMONIATE; GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) ; GLYCYRRHIZIN AMMONIUM SALT; GYLCYRRHI ZIC ACID AMMONIUM SALT; MONOAMMONIUM GLYCYRRHIZINATE; MONOAMMONIUM ALPHA-GLYCYRRHIZINATE; AMMONIATE (3B,20B ) -20-CARBOXY-11-OXO-30-NORLEAN-12-EN-3-YL-2-O-B -D-GLUCOPYRANURONOSYL-; AMMONIATED (GLYCYRRHIZA SPP.) GLYCYRRHIZIN; AMMONIATED GLYCYRRHIZIN
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Restrictions & warnings |
 | Allergies/immunotoxicity |
| Contamination concerns |
| Lesser or emerging concerns for this ingredient: Neurotoxicity, Endocrine disruption, Organ system toxicity (non-reproductive), Data gaps, Biochemical or cellular level changes |
|
See products containing AMMONIUM GLYCYRRHIZATE | |
About AMMONIUM GLYCYRRHIZATE: Ammonium Glycyrrhizate is the ammonium salt of Glycyrrhizic Acid (q.v.).
AMMONIUM GLYCYRRHIZATE has reported used in the following product types: lip balm (29); lipstick (11); lip gloss (11); sunscreen: lip balm (9); body firming lotion (4); oral pain relief (3); facial cleanser (3); antiperspirant/deodorant (3); anti-aging (3); toothpaste (2)
Cancer
| type of concern | product conditions | reference |
| One or more in vitro tests on mammalian cells show positive mutation results | RTECS®- National Technical Information Service | |
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Restrictions & warnings
| type of concern | product conditions | reference |
| Determined safe for use in cosmetics, subject to concentration or use limitations - Restrictions on impurities recommended by industry safety panel | Cosmetic Ingredient Review Assessments |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient) | RTECS®- Farmakologiya i Toksikologiya (Moscow) 1988 | |
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Endocrine disruption
| type of concern | product conditions | reference |
| One or more animal studies show endocrine system disruption at high doses | RTECS®- Neurobehavioral Toxicology and Teratology 1981 |
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain, nervous system, or behavioral effects at high doses | RTECS®- Farmakologiya i Toksikologiya (Moscow) 1988 |
Developmental/reproductive toxicity
| type of concern | product conditions | reference |
| One or more animal studies show reproductive effects at high doses | RTECS®- Food and Chemical Toxicology 1988 | |
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Biochemical or cellular level changes
| type of concern | product conditions | reference |
| One or more animal studies show biochemical changes at moderate doses where the human health implications are not yet well understood | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1997 | |
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Data gaps
| type of concern | product conditions | reference |
| Considered safe based on assumption of low absorption | Cosmetic Ingredient Review Assessments | |
| Risk assessment method deficiencies and data gaps - Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product | Cosmetic Ingredient Review Assessments | |
| 10 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Persistence and bioaccumulation
| type of concern | product conditions | reference |
| Not suspected to be bioaccumulative | Environment Canada Domestic Substance List |
Multiple, additive exposure sources
| type of concern | product conditions | reference |
| Designated as safe for general or specific, limited use in food | FDA Everything Added to Food |
Ecotoxicology
| type of concern | product conditions | reference |
| Not suspected to be an environmental toxin | Environment Canada Domestic Substance List |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| Cosmetic Ingredient Review Assessments | AMMONIUM GLYCYRRHIZATE | •Safe as used in cosmetics according to industry panel (Cosmetic Ingredient Review, CIR) •Maximum reported "as used" concentration is basis of safety assessment by industry safety panel (Cosmetic Ingredient Review, CIR) - implicit safe concentration limit in product •Restrictions on impurities recommended by industry safety panel •May contain harmful impurities •Determined safe for use in cosmetics based on assumption of low absorption through skin |
| FDA Everything Added to Food | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) | • Fully up-to-date toxicology information has been sought. |
| Environment Canada Domestic Substance List | _-D-GLUCOPYRANOSIDURONIC ACID, (3ß,20ß)-20-CARBOXY- 11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-ß-D-GLUCOPYRANURONOSYL-, MONOAMMONIUM SALT | •This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for suspected persistence. |
| IFRA Fragrance Ingredient List | .ALPHA.-D-GLUCOPYRANOSIDURONIC ACID, (3.BETA.,20.BETA.)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANURONOSYL-, MONOAMMONIUM SALT | •The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008. |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1997 | AMMONIUM GLYCYRRHIZATE | • liver - Hepatitis (hepatocellular necrosis), diffuse (rat TDLo) • blood - Changes in leucocyte (WBC) count (rat TDLo) • biochemical - Phosphatases (rat TDLo) |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1997 | AMMONIUM GLYCYRRHIZATE | • broad systemic - Broad systemic toxicity (mouse LD) • blood - Changes in leucocyte (WBC) count (rat TDLo) • biochemical - Dehydrogenases (rat TDLo) • liver - Hepatitis (hepatocellular necrosis), zonal (rat TDLo) • biochemical - Multiple enzyme effects (rat TDLo) • kidney or renal system - Other changes (rat TDLo) |
| RTECS®- Environmental Mutagenesis 1986 | AMMONIUM GLYCYRRHIZATE | • reproductive - Pre-implantation mortality (rat TDLo) • mutagenic - Positive mutation assay: Dominant Lethal Strain (rat orl) |
| RTECS®- Farmakologiya i Toksikologiya (Moscow) 1988 | AMMONIUM GLYCYRRHIZATE | • broad systemic - Broad systemic toxicity (mouse LD) • respiratory - Cyanosis (rat TDLo) • respiratory - Dyspnea (rat TDLo) • liver - Liver function tests impaired (rat TDLo) • biochemical - Other enzymes (rat TDLo) • brain, nervous system, or behavioral effect - Somnolence (general depressed activity) (rat TDLo) • biochemical - Transaminases (rat TDLo) • kidney or renal system - Urine volume decreased (rat TDLo) |
| RTECS®- Food and Chemical Toxicology 1988 | AMMONIUM GLYCYRRHIZATE | • reproductive - Musculoskeletal system (rat TDLo) • reproductive - Urogenital system (rat TDLo) |
| RTECS®- National Technical Information Service | AMMONIUM GLYCYRRHIZATE | • mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse orl) |
| RTECS®- National Technical Information Service | AMMONIUM GLYCYRRHIZATE | • mutagenic - Positive mutation assay: Dominant Lethal Strain (mouse orl) |
| RTECS®- Neurobehavioral Toxicology and Teratology 1981 | AMMONIUM GLYCYRRHIZATE | • endocrine system - Changes in adrenal weight (rat TDLo) • kidney or renal system - Changes in bladder weight (rat TDLo) • cardiovascular - Changes in heart weight (rat TDLo) |
| RTECS®- Yaoxue Tongbao 1987 | AMMONIUM GLYCYRRHIZATE | • broad systemic - Broad systemic toxicity (mouse LD50) |
references
| government/industry list/academic study | reference |
| Cosmetic Ingredient Review Assessments | CIR (Cosmetic Ingredient Review). 2006. CIR Compendium, containing abstracts, discussions, and conclusions of CIR cosmetic ingredient safety assessments. Washington DC. |
| FDA Everything Added to Food | FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition. |
| Environment Canada Domestic Substance List | EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry. |
| IFRA Fragrance Ingredient List | IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25 |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1997 | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 60(2),65,1997 |
| RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya 1997 | RTECS®- Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992- 60,65,1997 |
| RTECS®- Environmental Mutagenesis 1986 | RTECS®- Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. 8,357,1986 |
| RTECS®- Farmakologiya i Toksikologiya (Moscow) 1988 | RTECS®- Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- 51,87,1988 |
| RTECS®- Food and Chemical Toxicology 1988 | RTECS®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 26,435,1988 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB279-650 |
| RTECS®- National Technical Information Service | RTECS®- National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. PB279-650 |
| RTECS®- Neurobehavioral Toxicology and Teratology 1981 | RTECS®- Neurobehavioral Toxicology and Teratology. (Fayetteville, NY) V.3-8, 1981-86. For publisher information, see NETEEC. 3,37,1981 |
| RTECS®- Yaoxue Tongbao 1987 | RTECS®- Yaoxue Tongbao. Bulletin of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.13-23, 1978-88. For publisher information, see ZYZAEU. 22,449,1987 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
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