COFFEA ARABICA (ARABIAN COFFEE) || Skin Deep: Cosmetic Safety Reviews

COFFEA ARABICA (ARABIAN COFFEE)

PERFUMING

SCORE

	2	low hazard
	80%	data gap
(why scores have changed)

Also listed as

COFFEA ARABICA (ARABIAN COFFEE) SEEDS; COFFEE; COFFEA ARABICA; ARABIAN COFFEE

Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.

This ingredient:
	Cancer
	Developmental/reproductive toxicity
	Restrictions & warnings
	Allergies/immunotoxicity
	Contamination concerns
	Lesser or emerging concerns for this ingredient: Organ system toxicity (non-reproductive), Data gaps
	See products containing COFFEA ARABICA (ARABIAN COFFEE)

COFFEA ARABICA (ARABIAN COFFEE) has reported used in the following product types: bar soap (13); exfoliant/scrub (8); anti-aging (5); facial moisturizer/treatment (4); moisturizer (3); bath oil/salts/soak (3); mask (3); mascara (2); personal cleansing (2); body wash/cleanser (2)

Cancer

type of concern

product conditions

reference

Limited evidence of carcinogenicity

Int'l Agency for Research on Cancer (IARC) - Carcinogens

Organ system toxicity (non-reproductive)

type of concern

product conditions

reference

One or more animal studies show broad systemic effects at moderate doses (low dose studies may be unavailable for this ingredient)

RTECS^®- Indian Journal of Experimental Biology 1971

Developmental/reproductive toxicity

type of concern

product conditions

reference

One or more animal studies show reproductive effects at high doses

RTECS^®- Toxicology and Applied Pharmacology 1981

Data gaps

type of concern	product conditions	reference
Not assessed for safety in cosmetics by industry panel
1,218 studies in PubMed science library may include information on the toxicity of this chemical see search results ->		PubMed

Multiple, additive exposure sources

type of concern	product conditions	reference
Designated as safe for general or specific, limited use in food		FDA Everything Added to Food
Designated as safe for general or specific, limited use in food		FDA Food Additive Status

Ecotoxicology

type of concern	product conditions	reference
Not suspected to be an environmental toxin		Environment Canada Domestic Substance List

Government, industry, academic studies and classifications

government/industry list/academic study	appears on list as	classification(s)
FDA Food Additive Status	COFFEE	• Food additive: essential oil and/or oleoresin (solvent free) • GRAS (generally recognized as safe) - use in food presumed safe based either on a history of use before 1958 or on published scientific evidence; need not be approved by the FDA prior to use in food; most have not limit for use but must conform to good manufacturing practices; some GRAS substances have quantitative limit for use in foods; by definition under Sec 201(s) of FD&C Act, not food additives - CFR182.20
FDA Everything Added to Food	COFFEE EXTRACT (COFFEA SPP.)	• Fully up-to-date toxicology information has been sought.
Environment Canada Domestic Substance List	COFFEE	•This chemical was NOT flagged by CEPA for further attention. The chemical was flagged for uncertain persistence and uncertain bioaccumulation.
IFRA Fragrance Ingredient List	COFFEE, COFFEA ARABICA, EXT.	•The chemical has been reported as used in fragrance compounds by IFRA affiliated member companies in 2008.
Int'l Agency for Research on Cancer (IARC) - Carcinogens	COFFEE (URINARY BLADDER)	•IARC Group 2B: possible human carcinogen (International Agency for Research on Carcinogens)
RTECS^®- Cancer Detection and Prevention 1981	COFFEA ARABICA (ARABIAN COFFEE)	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS^®- Environmental Mutagenesis 1987	COFFEA ARABICA (ARABIAN COFFEE)	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS^®- Food and Chemical Toxicology 1986	COFFEA ARABICA (ARABIAN COFFEE)	• mutagenic - Positive mutation assay: (Drosophila melanogaster orl) • mutagenic - Positive mutation assay: Dominant Lethal Strain (Drosophila melanogaster orl) • mutagenic - Positive mutation assay: Sex Chromosome Loss and Nondisjunction (Drosophila melanogaster orl)
RTECS^®- Indian Journal of Experimental Biology 1971	COFFEA ARABICA (ARABIAN COFFEE)	• broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^®- Mutagenesis 1989	COFFEA ARABICA (ARABIAN COFFEE)	• mutagenic - Positive mutation assay: Sister Chromatid Exchange ( human lym)
RTECS^®- Mutation Research 1983	COFFEA ARABICA (ARABIAN COFFEE)	• mutagenic - Positive mutation assay: Mutation in Micro-organism (Escherichia coli ) • mutagenic - Positive mutation assay: Phage Inhibition Capacity (Escherichia coli )
RTECS^®- Toxicology and Applied Pharmacology 1978	COFFEA ARABICA (ARABIAN COFFEE)	• reproductive - Craniofacial (rat TDLo) • reproductive - Urogenital system (rat TDLo)
RTECS^®- Toxicology and Applied Pharmacology 1981	COFFEA ARABICA (ARABIAN COFFEE)	• reproductive - Growth statistics (rat TDLo) • reproductive - Musculoskeletal system (rat TDLo)

references

government/industry list/academic study	reference
FDA Food Additive Status	FDA (U.S. Food and Drug Administration) 2006. Food Additive Status List. Downloaded from http://www.cfsan.fda.gov/%7Edms/opa-appa.html, Oct 16, 2006.
FDA Everything Added to Food	FDA (U.S. Food and Drug Administration). 2008. EAFUS [Everything Added to Food]: A Food Additive Database. FDA Office of Food Safety and Applied Nutrition.
Environment Canada Domestic Substance List	EC (Environment Canada). 2008. Domestic Substances List Categorization. Canadian Environmental Protection Act (CEPA) Environmental Registry.
IFRA Fragrance Ingredient List	IFRA (International Fragrance Assocication). 2010. IFRA Fragrance Ingredient List based on 2008 Use Survey. Accessed online 01/04/2010: http://www.ifraorg.org/Home/News/Latest-News/page.aspx/66?xf_itemId=43&xf_selectionDatapartId=25
Int'l Agency for Research on Cancer (IARC) - Carcinogens	IARC (International Agency for Research on Cancer). 2008. Overall Evaluations of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes 1-99 (a total of 935 agents, mixtures and exposures).
RTECS^®- Cancer Detection and Prevention 1981	RTECS^®- Cancer Detection and Prevention. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1976- 3,507,1981
RTECS^®- Environmental Mutagenesis 1987	RTECS^®- Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. 9,251,1987
RTECS^®- Food and Chemical Toxicology 1986	RTECS^®- Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- 24,835,1986
RTECS^®- Indian Journal of Experimental Biology 1971	RTECS^®- Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- 9,91,1971
RTECS^®- Mutagenesis 1989	RTECS^®- Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- 4,343,1989
RTECS^®- Mutation Research 1983	RTECS^®- Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 116,179,1983
RTECS^®- Toxicology and Applied Pharmacology 1978	RTECS^®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 44,1,1978
RTECS^®- Toxicology and Applied Pharmacology 1981	RTECS^®- Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- 58,171,1981

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