NISIN
Preservative; ANTIMICROBIAL
Given the incomplete information made available by companies and the government, EWG provides additional information on personal care product ingredients from the published scientific literature. The chart below indicates that research studies have found that exposure to this ingredient -- not the products containing it -- caused the indicated health effect(s) in the studies reviewed by Skin Deep researchers. Actual health risks, if any, will vary based on the level of exposure to the ingredient and individual susceptibility -- information not available in Skin Deep.
| This ingredient: | |
 | Cancer |
| Developmental/reproductive toxicity |
| Restrictions & warnings |
| Allergies/immunotoxicity |
| Contamination concerns |
 | Other moderate concerns for this ingredient: Neurotoxicity, Organ system toxicity (non-reproductive) |
 | Lesser or emerging concerns for this ingredient: Data gaps |
|
See products containing NISIN | |
About NISIN: Nisin Is a polypeptide produced by the fermentation of Lactococcus lactis.
NISIN has reported used in the following product types: anti-aging (6); moisturizer (6); mask (5); facial moisturizer/treatment (1)
Neurotoxicity
| type of concern | product conditions | reference |
| One or more animal studies show brain, nervous system, or behavioral effects at very low doses | RTECS®- British Journal of Pharmacology and Chemotherapy 1952 |
Organ system toxicity (non-reproductive)
| type of concern | product conditions | reference |
| One or more animal studies show broad systemic effects at low doses | RTECS®- "CRC Handbook of Antibiotic Compounds," Vols 1980 | |
| show more | ||
Data gaps
| type of concern | product conditions | reference |
| Not assessed for safety in cosmetics by industry panel | ||
| 370 studies in PubMed science library may include information on the toxicity of this chemical see search results -> | PubMed |
Government, industry, academic studies and classifications
| government/industry list/academic study | appears on list as | classification(s) |
| RTECS®- "CRC Handbook of Antibiotic Compounds," Vols 1980 | NISIN | • broad systemic - Broad systemic toxicity (mouse LD50) |
| RTECS®- British Journal of Pharmacology and Chemotherapy 1952 | NISIN | • brain, nervous system, or behavioral effect - Meningeal changes (rabbit LDLo) • brain, nervous system, or behavioral effect - Changes in cerebral spinal fluid (rabbit LDLo) • brain, nervous system, or behavioral effect - Irritability (rabbit LDLo) • cardiovascular - Thrombosis distant from injection site (rabbit TDLo) |
references
| government/industry list/academic study | reference |
| RTECS®- "CRC Handbook of Antibiotic Compounds," Vols 1980 | RTECS®- "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- 4(2),228,1980 |
| RTECS®- British Journal of Pharmacology and Chemotherapy 1952 | RTECS®- British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. 7,438,1952 |
"RTECS®" is a United States trademark owned and licensed under authority of the U.S. Government, by and through MDL Information Systems, Inc.
Copyright © 2010 by Environmental Working Group
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